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Polyphenols, Mitochondria, Glial Cells & Neurodegenrative Pathway Studies (draft)

Last updated on May 8, 2023

I spent a great deal of time this past week investigating the organic chemistry dynamics of the ACS study Mechanistic Insights into Polyphenols’ Aggregation Inhibition of α-Synuclein and Related Peptides. This study only examined the impact of resveratrol & gallic acid on the aggregation of α-synuclein & its results showed that rather than disrupting α-synuclein aggregation the polyphenols merely became weakening elements of a broadened sheet. Importantly, the narrow scope of this research excluded consideration of whether the toxicity to glial cells of this disease causing protein was lessened & their dutiful activities excited by the studied polyphenols.

Here I am interested in the vitality of glial mitochondria & their susceptiblity to problematic exposure mitophagy which requires having evidence of how the citric acid cycle for its energy production (ATP reservoir on/off switch) is affected by disease conditons.

…. more to come (Creative Commons image uploads await discussion & pairings)

Six types of gliocytes in the central and the peripheral nervous system: oligodendrocyte, astrocyte, ependymal cell, microglia, Schwann and satellite cell.
Ribosome during protein synthesis. The Interaction of a Ribosome with mRNA. Process of initiation of translation

Axial section through mid-brain. (Schematic.) (Testut.) 1. Corpora quadrigemina. 2. Cerebral aqueduct. 3. Central gray stratum. 4. Interpeduncular space. 5. Sulcus lateralis. 6. Substantia nigra. 7. Red nucleus of tegmentum. 8. Oculomotor nerve, with 8’, its nucleus of origin. a. Lemniscus (in blue) with a’ the medial lemniscus and a” the lateral lemniscus. b. Medial longitudinal fasciculus. c. Raphé. d. Temporopontine fibers. e. Portion of medial lemniscus, which runs to the lentiform nucleus and insula. f. Cerebrospinal fibers. g. Frontopontine fibers.

Brainstem nuclei involved in human emotion. (A) Sagittal view and (B) Coronal view. DR, Dorsal Raphe; LC, Locus coeruleus; LDT, Laterodorsal tegmental nucleus; Mb, Midbrain; MR, Median raphe; P, Pons; PAG, Periaqueductal gray; PBC, Parabrachial nuclear complex; PPN, Pedunculopontine nucleus; VTA, Ventral tegmental area. The substantia nigra and the nucleus of the tractus solitarius are not shown to optimize visibility of the other structures.

New Frontiers in Parkinson’s Research and Care 


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